IGFBP5 and cancer: Targets of hsa-miR-532-5p such as runt-related transcription factor-3 (Peng et al., 2006; Kim et al., 2016), insulin-like growth factor-binding protein-5 (Rho et al., 2008; Lee et al., 2016), and von Hippel-Lindau (Kong et al., 2011, 2014; Lu et al., 2013) were proved to be associated with angiogenesis in many types of cancer.