Consequently, statins have been shown in preclinical in vitro and in vivo studies to modulate signaling molecules including H-, K-, and N-Ras, Raf-1, nuclear factor kappa B (NFκB), mitogen-activated protein kinases (MAPKs), PI3K/AKT, extracellular signal-regulated kinase (ERK), mTOR, signal transducer and activator of transcription 3 (STAT3), Janus kinase 2 (JAK2) and caspases, suppress cell proliferation and cell cycle progress, and induce tumor cell apoptosis (Hindler et al., 2006; Pisanti et al., 2014; Chen et al., 2015; Ahmadi et al., 2017; Beckwitt et al., 2018; Kong et al., 2018). The gene discussed is STAT3; the disease is neoplasm.