Ianowski et al. (2007) suggested that the murine trachea is an appropriate tissue for studying airway glands abnormalities in CF (Ianowski et al., 2007). Airway SMGs are found in the proximal trachea of mice. In the cartilaginous rings, CFTR expression is found at the highest levels in SMG serous tubules as reported by Engelhardt et al. (1992). Furthermore, it is well known that serous cells secrete antimicrobial proteins, such as lysozyme and lactoferrin, indicating the importance of tracheal glands in CF disease (Engelhardt et al., 1992). This evidence concerns the gene CFTR and cystic fibrosis.