Originally developed to study airway diseases, such as bronchial asthma (Hamidi et al., 2006; Szema et al., 2006; Said, 2009), VIP-KO mice were used by Alcolado et al. (2014) to demonstrate the molecular link between VIP and CFTR regulation in the airways and small intestines, and observed a CF-like phenotype. Here, VIP is linked to cystic fibrosis.