Recently, a Chinese study demonstrated that circulating Helios+Tregs are significantly decreased in acute coronary syndrome and the estimated absolute numbers of CD4+Foxp3+Helios+ Tregs were negatively correlated with IL-6 and positively correlated with circulating levels of the transforming growth factor beta1 (TGF-beta1) and HDL-C in these patients [43]. The gene discussed is CD4; the disease is acute coronary syndrome.