PTGS1 and edema: Inthe carrageenan-induced rat paw edema model, AmLexin resulted in 46.3–53.3%reductions in paw edema and 43.6–54.8% reductions in pain sensitivity (commoncardinal signs of inflammation) compared to the vehicle-treated control19.IC50 (concentration causing 50% inhibition) values for majorinflammation-mediating enzymes, such as cyclooxygenase 1 (COX-1), cyclooxygenase 2(COX-2), and 5-lipoxygenase (5-LOX), were found to be 20.9 μg/mL, 49.2μg/mL, and 11.1 μg/mL, respectively19.