NF‐κB activation is known to be mediated through the Akt/IKK‐β pathway.20, 21 Previous study has demonstrated that RPS15A is involved in the activation of the Akt pathway in glioblastoma.15 Thus, we hypothesized that RPS15A might activate NF‐κB through the Akt/IKK‐β pathway in GC cells. This evidence concerns the gene RPS15A and gastric cancer.