Because the role of PTPRJ in cancers has been widely described and many studies confirm its role in this process, we may suppose that the location of Gln276Pro (rs1566734) and Arg326Gln (rs1503185) polymorphisms in PTPRJ or amino acid changes and what they underlie are not important for the role of PTPRJ in carcinogenesis. This evidence concerns the gene PTPRJ and cancer.