EGFR and non-small cell lung carcinoma: In addition, brain metastasis after treatment (Fig. 2e) and new metastasis site (Fig. 3a) are also two predictive factors for shortening of PFS in NSCLC patients treated with EGFR TKI, HR = 2.38 (P = 0.005), and 2.51 (P < 0.001), respectively.