Moreover, PD‐L2 expression in blood samples of OSCC patients suffering from lymph node metastases (N+) did not show higher expression than in blood samples of patients without metastases (N0) (mean ∆CT N+ 10.51, mean ∆CT N0 11.13; P = 0.141) (Table 4). This evidence concerns the gene PDCD1LG2 and metastatic malignant neoplasm in the lymph nodes.