PDCD1LG2 and malaria: Recent findings suggest a novel role for PD‐L2 in enhancing T‐cell immunity.22 Blocking PD‐L2 in a malaria mouse model led to increased numbers of regulatory T cells and diminished T‐cell activation.22, 23 Additionally, PD‐L2 inhibition was associated with increased lethality of the disease.22 This underlines our incomplete understanding of the regulation of PD/PD‐L signaling and implies that PD‐L2 might also act as immune activation ligand in certain conditions.