PDCD1LG2 and neoplasm: It was shown that PD‐L2 expression can be found on Th2 polarized cells in contrast to Th1, Th17, or Treg cells, which are negative for PD‐L2 expression.34 Therefore, the increase in PD‐L2 expression in OSCC could be associated with an increased Th2 polarization of the tumor‐associated T cells.