Human TM cells treated with TGFβ2 also increase the level of plasminogen activator inhibitor (PAI), fibronectin, collagen and the promatrix metalloproteinase‐2.40, 41, 48, 49 In summary, TGF‐βs, especially TGF‐β2, play an important role in pathogenesis of glaucoma. This evidence concerns the gene SERPINB2 and glaucoma.