Therefore, increased PAI‐1 leads to decreased activation of MMPs and may contribute to the increase in ECM of TM in glaucomatous eyes.42 It is also well documented that in glaucoma, MMPs are altered, as are their inhibitory enzymes, TIMPs.43 Therefore, the dysregulation of MMPs by increased levels of TGF‐β2 may contribute to the decreased degradation of ECM and abnormal organization commonly seen in the TM of patients with glaucoma. The gene discussed is SERPINE1; the disease is glaucoma.