TGFβ is involved in the pathogenesis of glaucoma.41 Higher levels of TGFβ2 in AH are associated with increased ECM content and IOP.20, 23, 46, 47 TM cells treated with TGFβ1 or TGFβ2 express ECM genes, including collagens, elastin, fibrillin, laminin and versican. The gene discussed is TGFB2; the disease is glaucoma.