CD4 and infection: A series of high-resolution, genome-wide measurements of the transcriptome, proteome, and phosphoproteome were conducted in uninfected and infected SupT1 CD4+ T cells in order to define the dynamic, integrated proteo-transcriptomic response of the cell to infection with an HIVeGFP vector and to understand the key molecular players maintaining a balance between host support for viral replication and host defense response to inhibit infection (Fig. 1).