Furthermore, we found an elevation of C/EBPβ eRNA level in HCC tumor compared to non-tumor tissues, which exhibited significantly negative and positive correlations with C/EBPβ enhancer methylation (P < 0.05; Fig. 2i) and C/EBPβ mRNA levels (P < 0.01; Fig. 2j), respectively, thus verifying the clinical relevance of our findings. This evidence concerns the gene CEBPB and hepatocellular carcinoma.