CEBPB and neoplasm: To elucidate the biological and functional significance of C/EBPβ enhancer in tumor development, we generated monoallelic (C/EBPβ enh+/−) and biallelic (C/EBPβ enh−/−) deletion of C/EBPβ enhancer via CRISPR/Cas9 in HepG2 and LO2 cells (Fig. 4a and Supplementary Fig. 5).