For example, Ras like proto-oncogene B (RALB)44, a key mediator of metabolic and mitogenic pathways in HCC, was markedly downregulated in C/EBPβ enh−/− cells, which were associated with a notable decrease in the co-occupancy of C/EBPβ, BRD4, and H3K27ac at its super-enhancer region (Fig. 6i). The gene discussed is BRD4; the disease is hepatocellular carcinoma.