BRD4 and cancer: Gene ontology (GO) analyses43 of the 805 super-enhancer- and 1817 enhancer-target genes whose activities were co-regulated by C/EBPβ and BRD4 (Fig. 6f) uncovered regulators of cancer pathways such as small GTPase-mediated signal transduction, and effectors of cell migration, proliferation, and vasculature development (Fig. 6g, h), consistent with the drastic inhibition of tumorigenicity in C/EBPβ enh−/− cells (Fig. 4).