In contrast, the C/EBPβ promoter methylation levels were invariable among the tumor and non-tumor tissues, exhibiting low methylation levels ( < 2%) at the 26 CpGs encompassing the C/EBPβ transcription start site (TSS, −561 to + 458-bp; Supplementary Fig. 1a). This evidence concerns the gene CEBPB and neoplasm.