CEBPB and neoplasm: As we also showed its upregulation and correlations with both C/EBPβ enhancer hypomethylation and mRNA expression in human HCCs, our findings concur with the functional significance of other tumor-specific eRNAs, such as androgen- and estrogen-dependent eRNAs in prostate28 and breast cancers29 that play indispensable roles in gene transcription programs11.