MYC and hyperplastic polyp: We therefore repeated the deletion experiments described above using cells from Lsd1-iKO MP tumors, which are driven by overexpression of Myc and DNp53. As shown in Supplementary Fig. 6a–c, loss of Lsd1 had a much more modest effect on MP tumors than it did on MG tumors: the majority of animals receiving 4-OHT-treated Lsd1-iKO MP tumor cells still developed tumors.