MIR205HG and prostate adenocarcinoma: In this work we characterize for the first time the expression pattern and role of MIR205HG, showing that (i) MIR205HG is mainly expressed in the basal layer of prostate epithelium and lost in PRAD, (ii) the Drosha-mediated processing of specific alternative transcripts of the gene is responsible for miR-205 production, and (iii) MIR205HG functions independently of the hosted miRNA as nuclear intergenic long noncoding RNA (lincRNA) capable of regulating basal-luminal differentiation through repression of the interferon pathway.