In brief, the found associations could be due to: (1) genetic variants, e.g., I405V Cholesteryl ester transfer protein (CETP) which is associated with improved cognitive function, as well as higher HDL-C levels in the elderly,3 (2) vascular changes given that HDL-C is inversely associated with lacunar infarction independently of other CVD risk factors,38 and (3) interactions between HDL-C apolipoproteins and amyloid beta protein, a hallmark peptide of AD.39 Apolipoproteins promote the degradation of amyloid beta protein,40 as well as prevent its aggregation into amyloid.41 Here, CETP is linked to Alzheimer disease.