TRIM65 and Stroke: We also confirmed 2 previous associations at genome-wide significance: one at 17q25, localizing to TRIM47 and TRIM65 (rs3744020; β [SE] = 0.106 [0.016]; p = 1.2 × 10−11), and a second on chromosome 2, close to EFEMP1 (rs7596872; β [SE] = 0.143 [0.021]; p = 3.4 × 10−12).4,5 For all 3 loci, there was no evidence of heterogeneity either within the WMH in Stroke cohorts or between the WMH in Stroke and UK Biobank datasets (table; forest plots data available from Open Science Framework [figures e-5 and e-6; osf.io/pkruv]).