The PLEKHG1 SNP (rs275350) was associated with all ischemic stroke (odds ratio [OR] [95% confidence interval (CI)] 1.07 [1.03–1.12], p = 0.00051; figures 1–3), most strongly with the small vessel subtype (OR [95% CI] 1.09 [1.00–1.19], p = 0.044). This evidence concerns the gene PLEKHG1 and ischemic stroke.