GH1 and Prader-Willi syndrome: PWS is characterised by its nutritional phases from initial feeding difficulties and failure-to-thrive in infancy, to progressive hyperphagia and morbid obesity (if access to food is not controlled) from later childhood to adulthood, growth hormone (GH) and sex hormone deficiencies, secondary to hypothalamic dysfunction (Miller et al., 2007; Goldstone et al., 2008; Goldstone et al., 2012), and possible pro-hormone/−neuropeptide precursor processing defects (Burnett et al., 2017).