To date no manuscript has been published on MΦ subsets in OA SF, as defined by CD14 and CD16 markers; however, studies in RA and juvenile idiopathic arthritis SFs show that the double-positive CD14+CD16+−MΦ subset is increased in SF MΦs when compared to circulating MΦs [21–23]. This evidence concerns the gene CD14 and juvenile idiopathic arthritis.