A positive correlation was found between the numbers of tumor-infiltrating CD8–Foxp3+Tbet+ Tregs, CD8–Foxp3–Tbet+ (CD4) T cells and CD8 + Foxp3–Tbet+ T cells, supporting the notion that CD8–Foxp3+Tbet+ Tregs accumulate at similar sites as type 1-oriented (Foxp3-) effector T cells. Here, TBX21 is linked to neoplasm.