CRP and rheumatoid arthritis: Interestingly, when we performed a retrospective subanalysis of disease activity for the 2 years prior to the periodontitis evaluation in the 56 RA patients treated with bDMARDs, we observed that those with periodontitis Level 0 or 1 had a significantly lower mean disease activity (as assessed by DAS28-CRP; 3.29 ± 1.16, n = 31) than patients with Level 2 periodontitis (3.74 ± 1.23, n = 25) (p = 0.0046).