High coexpression levels of ZDHHC18 and ZDHHC23 (> median value) had a significantly worse prognosis than low co-expression levels in the patients with GBM (7.91 vs. 19.37 months for OS, p < 0.05; 7.38 vs. 13.17 months for DFS, p < 0.01). This evidence concerns the gene ZDHHC18 and glioblastoma.