This association still strengthened after controlling for potentially confounding variables (adjust I controlling for: smoking, histological type, stage of cancer, triglyceride, PT, APTT and CRP; adjust II controlling for: sex, age, smoking, location of lesion, histological type, stage of cancer, triglyceride, apolipoprotein E, PT, APTT, neutrophils and CRP) in in multiple regression analysis. The gene discussed is CRP; the disease is cancer.