Authors also suggested that the release of β-hexosaminidase from degranulated mast cells, high levels of serum immunoglobulin (Ig)E, and the expression of proinflammatory mediators such as prostaglandin E2 (PGE2) and nitrite (NO) are important determinants in the propensity of mice to AD [8, 9]. Here, IGHE is linked to Alzheimer disease.