Additionally, patient comorbidities and menopausal status, tumor histology and pathology, hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) status, sites of metastatic involvement, number of involved axillary lymph nodes and de novo metastatic disease presentation are also considered prognostic factors of survival and treatment response [9–11]. This evidence concerns the gene ERBB2 and metastatic neoplasm.