Kv1.3, a voltage-gated K+ channel that amongst others associates with KCa3.1 for immune activation [88], was already shown to induce mitochondria-dependent apoptosis in lymphocytes [89] but also in cancer cell lines as well as in vivo melanoma and pancreatic cancer models [90,91]. The gene discussed is KCNN4; the disease is familial pancreatic carcinoma.