LYPD5 and breast cancer: It is therefore of interest that the SNP rs3760982 located at the intergenic region of KCNN4 and LYPD5 (LY6/PLAUR Domain Containing 5, metastasis-associated protein) on chromosome 19q13.31 has been shown to be associated with breast cancer risk [27], a finding that was corroborated in large scale genome wide association studies (GWAS) using data sets of more than 200,000 patients and controls (P = 1.4 × 10−16 [28]).