Among the reporter TFs, AR is dysregulated in the prostate cancer [61]; ETS is involved in different types of cancers [62]; GATA2 is deregulated in CRC with poor survival outcomes [63]; GATA3 and GATA4 were proposed to be implicated in different cancers [64]; YBX1 and FOXP3 are markers of cancers [65,66,67]; E2F4 disruption is involved in cancers [68,69]; the dysregulation of PRDM14 and ESR1 is found in breast cancers [70,71,72]. The gene discussed is ESR1; the disease is Familial prostate cancer.