The survival analysis of the hub genes, TFs, and miRNAs clarified that these gene signatures (MYC, CENPN, RFC, CENPA, CEBPB, ADNP, CDK4, CCND1, CENPH, and CD44) have high potentiality of being prognostic biomarkers in CRC. The gene discussed is CDK4; the disease is colorectal carcinoma.