The prognostic survival analysis of the identified reporter biomolecules revealed proteomic signatures consisting of hub proteins (MYC, CENPN, RFC, CENPA, CEBPB, ADNP, CDK4, CCND1, CENPH, and CD44), and regulatory signatures consisting of TFs (AR, GATA1, GATA2, GATA3, EST1, YBX1, PRADM14, ESR1, E2F4, and FOXP3) and miRNAs (miR-193b-3p and miR-615-3p) as prognostic biomarker candidates in CRC. This evidence concerns the gene YBX1 and colorectal carcinoma.