ESR1 and colorectal carcinoma: Considering a statistical significance level of adj-p < 0.01, we identified 10 TFs (ETS1, ESR1, GATA1, GATA2, GATA3, AR, YBX1, FOXP3, E2F4, and PRDM14) and 10 miRNAs (miR-16-5p, miR-26b-5p, miR-124-3p, let-7b-5p, miR-92a-3p, miR-192-5p, miR-155-5p, miR-93-5p, miR-193b-3p, and miR-17-5p) as the mutual transcriptional regulatory components in both CRC datasets (Table 3).