KRIT1 and cerebral cavernous malformation: To investigate whether the upregulation of PSSG adducts observed in K−/− MEF cells could be recapitulated in a different cellular model, more strictly connected to CCM disease, we performed KRIT1 knockdown in human brain microvascular endothelial cells (hBMEC) according to a previously optimized siRNA-based procedure [9,20].