KRIT1 and cerebral cavernous malformation: Future studies aimed at an extended coverage of S-glutathionylated proteins associated with KRIT1 loss-of-function, including the use of a gel-free approach and a deep characterization of their functional implications, should provide useful insights for a better understanding of CCM disease pathogenesis, and new options for the identification of useful biomarkers and the development of targeted, safe and effective therapeutic strategies, which could benefit from the features of pleiotropy and reversibility of the PSSG process.