Interestingly, lncRNA-LBCS directly binds to the hnRNPK–EZH2 complex and guides it to the SOX2 promoter and induces H3K27me3 to inhibit SOX2 expression, contributing to the attenuation of bladder cancer initiation and chemoresistance. The gene discussed is HNRNPK; the disease is urinary bladder cancer.