In addition, PancEts-1 bound to the KH2 domain of hnRNPK to facilitate its physical interaction with β-catenin, while hnRNPK stabilized the β-catenin by inhibiting proteasome-mediated degradation, before increasing the nuclear translocation and activity of β-catenin, resulting in transcriptional alteration of the target genes associated with NB progression. This evidence concerns the gene HNRNPK and neuroblastoma.