Interestingly, while we observed a number of vasoprotective effects in relation to vascular inflammation, endothelial dysfunction, and vascular oxidative stress, these effects were independent of BP regulation, as i.p. injection of PGG at a dose of 10 mg·kg−1 every 2 days did not attenuate Ang II‐induced hypertension. The gene discussed is AGT; the disease is endothelial dysfunction.