PCSK9 and Sepsis: Understanding the link between LDL-C levels and sepsis is important because newer medications to lower lipid levels (ie, proprotein convertase subtilisin/kexin type 9 [PCSK9] inhibitors) can reduce LDL-C concentrations to very low levels.11,12 Also, administering lipoproteins to patients at risk for sepsis is a therapeutic strategy that could potentially prevent or ameliorate the disease.