TARBP2 and adrenal cortex carcinoma: However, TARBP2 functions as an oncogene to contribute to malignant transformation and proliferation in cutaneous malignant melanoma and adrenocortical carcinoma, and its expression is associated with an unfavorable prognosis in patients with breast cancer (Caramuta et al., 2013; Lin et al., 2014; Sand et al., 2012).