HES1 and colitis: Notably, aberrant expression of the Notch signalling pathway in the UC progression can lead to an increased expression of the transcription factor Hes‐1 (which inhibits the transcription factor ATOH1) to inhibit the differentiation of intestinal epithelial cells into goblet cells and thereby weaken the mucus barrier.8, 16, 17 Consequently, Notch activation and muc‐2/goblet cell depletion was observed in colitis model, which is consistent with previous reports.