Previous studies have shown that dysregulation of the differentiation system for prompt intestinal epithelial cell formation induces the pathology of intestinal diseases as ulcerative colitis (UC).8Therefore, we examined the status of Notch signalling (using immunostaining and immunoblotting) and the change in mRNA of Hes‐1 and ATOH1(using real‐time qPCR analysis). This evidence concerns the gene HES1 and intestinal disorder.