For instance, H3K27 acetylation‐mediated activation induces high expression of lncRNA CCAT1 in oesophageal squamous cell carcinoma,8 whereas the downregulation of p53‐induced lncRNA TP53TG1 is caused by the high methylation of its gene promoter.9 Additionally, upregulation of lncRNAs induced by its upstream transcription factor can promote tumour progression in various human cancers.10, 11, 12, 13 The dysregulation of lncRNAs has been identified as an oncogenic factor for the tumour progression.14, 15, 16, 17 Therefore, it is crucial to investigate the mechanism of lncRNAs in human cancers. The gene discussed is TP53; the disease is neoplasm.