Pervious study showed that IKKε could regulate GBM cell proliferation, migration, and invasion abilities in vitro and in vivo via the Hippo pathway.3 The research also revealed that IKKε could accelerate EMT of GBM cells.3 Another IKKε selective inhibitor, amlexanox was reported to generate antitumor effects by disrupting the Hippo pathway in human GBM cell lines.5 We guess that MCCK1 may inhibit IKKε to play anticancer role, but the regulatory mechanism of MCCK1 need to be further explored. This evidence concerns the gene IKBKE and glioblastoma.