It has been reported that Snail proteins involve in a variety of cellular processes through a number of different mechanisms.19 Previous studies have reported that overexpression of the Snail could facilitate the proliferation and invasion of gliomas cells.20 Therefore, we supposed that up‐regulation of 14‐3‐3ζ might promote Snail activation or expression, thereby inducing the increase of gliomas cells proliferation and invasion. This evidence concerns the gene SNAI1 and central nervous system cancer.