Snail is a vital inducer of EMT, and the overexpression of Snail correlates with tumor grade and metastasis and predicts a poor outcome with patients for various cancers.24 In gliomas cells, it has been reported that Snail could control the differentiation status of gliomas‐initiating cells by regulating BMP and TGF‐β pathways.25 These reports are consistent with our data, which proved that 14‐3‐3ζ overexpression promotes the migration and invasion of the gliomas cells. The gene discussed is SNAI1; the disease is central nervous system cancer.