AKT1 and neoplasm: 14‐3‐3ζ is one of the central proteins induced by TGF‐β, which can promote the epithelial‐mesenchymal transition in cancer cells.12 In addition, 14‐3‐3ζ can combine with the tumor suppressor tuberin to deter the phosphoinositide‐3′‐kinase signaling downstream of AKT.13