Previous studies have proved that activation of PI3K/AKT is able to increase the protein expression of Snail, subsequently promoting hepatocellular carcinoma (HCC) cells migration and invasion.26 Our data showed that PI3K/AKT was activated when 14‐3‐3ζ was overexpressed, and PI3K/AKT signaling inhibitors markedly attenuated the Snail expression triggered by 14‐3‐3ζ overexpression. This evidence concerns the gene SNAI1 and hepatocellular carcinoma.