PDZ‐binding kinase (PBK) is defined as a mitogen‐activated protein kinase between MEK7 and MEK1/2, a mitosis kinase that enhances cytokinesis as well as a kinase that promotes metastasis and cell migration in lung cancer.6 MicroRNA‐216b (miR‐216b) was recently demonstrated to play a repressive role in tumors by regulating the expression of PBK.7 According to the TargetScan database, there are theoretical complementary sequences between 3′‐untranslated region (UTR) of PBK and miR‐372. The gene discussed is PBK; the disease is lung cancer.