Moreover, we found that restoration of the expression of PBK up‐regulated the expression of Bcl‐2 but reduced that of p53, Caspase‐3, and Bax, suggesting that PBK inhibited apoptosis of NPC cells, and reversed the miR‐372‐induced activation of the p53 signaling pathway. This evidence concerns the gene BCL2 and nasopharyngeal carcinoma.