Up‐regulation of PBK could improve the growth of lung adenocarcinoma cells,38 and promoted the progression of esophageal squamous cell carcinoma.39 Similarly, miR‐770‐5p was shown to enhance radiosensitivity by suppressing PBK.26 Thus, the above‐mentioned results suggest that over‐expression of miR‐372 enhances radiosensitivity while inhibiting invasion and metastasis by negative regulation of PBK and activation of the p53 signaling pathway in NPC. This evidence concerns the gene PBK and esophageal squamous cell carcinoma.