In line with our study, another study demonstrated that over‐expression of miR‐24 promotes radiosensitivity via binding to specificity protein 1 in NPC.36 Also, miR‐206 has been demonstrated to increase NPC radiosensitivity via regulating IGF1.37 Moreover, over‐expression of PBK was revealed to contribute to increased colony formation, migration and invasion in NPC cells and tumor growth, while decreasing radiosensitivity in the current study. Here, SP1 is linked to nasopharyngeal carcinoma.