TCF7L2 and type 2 diabetes mellitus: In conclusion, these results indicate that high intakes of sweetened beverages increase the risk of both LADA and T2D, and that the effect is not amplified by genetic susceptibility conferred by genotypes of HLA, FTO or TCF7L2. The potential influence of sweetened beverages on diabetes risk seems to include effects on overweight as well as direct effects on insulin sensitivity.