Immunotherapy for LAGE-1 have been reported in other types of tumors, such as preclinical studies (McCormack et al. 2013) as well as adoptive cell transfer for melanoma (Kudela et al. 2011) and multiple myeloma (Rapoport et al. 2015), but there is no relevant study in esophageal cancer. This evidence concerns the gene CTAG2 and melanoma.