A truncated flagellin (tFL) with deletion of the hypervariable regions was used as a carrier by chemical conjugation with a malaria antigen M.RCAg-1 (M312), and compared with the physical mixture of M312 and tFL, the conjugates M312-PEG-tFL elicited higher M312-specific antibody titers (Guo et al., 2018). This evidence concerns the gene ZC3H12D and malaria.