The decreases and increases in oncogenic RAS by overexpression and knockdown of WDR76, respectively, were further confirmed using the three cancer cell lines harboring a RAS mutation (i.e., T24T bladder cancer cell line (HRASG12V), LoVo colon cancer cell line (KRASG13D), and HepG2 hepatocellular carcinoma cell line (NRASQ61L)) (Fig. 2h, i). Here, WDR76 is linked to colonic neoplasm.