Notably, the ectonucleotidase CD73, which is often overexpressed in cancer-associated Tregs [30], was significantly increased in P2X7 null mice not only on Tregs (Fig. 1i) but also on Teff cells (Fig. 1j) and CD11b+, Ly6Clow, F4/80+ macrophages (Fig. 1k). This evidence concerns the gene P2RX7 and cancer.