COPD is a highly complex inflammatory disease involving many cytokines and mediators, such that blocking a single cytokine does not have a clinically significant effect2, in the presence of systemic inflammation, including C-reactive protein (CRP), interleukin (IL)-6, fibrinogen, activated leukocytes, and tumor necrosis factor (TNF)-α3. The gene discussed is IL6; the disease is chronic obstructive pulmonary disease.