This study showed four major results: (1) distributions of Hp phenotypes differed between healthy participants and COPD patients; (2) concentrations of Hp phenotypes were positively significantly related to systemic inflammation and oxidative stress in COPD patients; (3) concentrations of Hp phenotypes were negatively related to the FEV1 in participants; and (4) serum concentrations of Hp phenotypes were significantly higher in COPD patients than in healthy participants. The gene discussed is HP; the disease is chronic obstructive pulmonary disease.