WNK2 and malignant colon neoplasm: To further characterize the mechanisms by which Kaempferol chemosensitizes the resistant colon cancer cells to 5-FU treatment, we analyzed the expression level of some proteins involved in JAK/STAT3, Wnt/β-catenin, mitogen activated protein kinases (MAPK) cascade, phosphatidyl-3-phosphate kinase (PI3K)/AKT and NF-κB signaling pathways that play critical role in the development and progression of colorectal cancer30.