Accordingly, this effect is in line with the work of Wiegering et al. 58 describing the major role of several small molecules (identified from the compound library of the National Cancer Institute) in inducing p53 activation and tumor apoptosis (RITA) which in turn enhance the antiproliferative response to 5-FU and increase the expression levels of p53 protein in colorectal cancer cells. Here, TP53 is linked to colorectal cancer.