For the small molecule/drug chemosensitisation screens, we plated COLO320DM cells (APC p.S811* homozygous and KRAS wild type) or SW480 cells (APC mutation p.N125K;p.F1197fs;p.S1278* heterozygous, KRAS mutation p.G12C heterozygous) in 384 well plates containing MSC2504877 or the drug vehicle (DMSO), combined with a library of 80 small molecule inhibitors that are either already used in the treatment of cancer, or are in late stage development. Here, APC is linked to cancer.