For example, NVP-TNKS656, a modification of XAV939, impairs the growth of Wnt-dependent lesions in the MMTV-Wnt1 mouse cancer model14,16, JW74 reduces tumour burden in the ApcMin mouse tumour model9 and JW55 impairs the proliferation of intestinal stem cells with Apc mutations in mice10. The gene discussed is APC; the disease is cancer.