APC and neoplasm: For example, NVP-TNKS656, a modification of XAV939, impairs the growth of Wnt-dependent lesions in the MMTV-Wnt1 mouse cancer model14,16, JW74 reduces tumour burden in the ApcMin mouse tumour model9 and JW55 impairs the proliferation of intestinal stem cells with Apc mutations in mice10.