Because MARCKS phosphorylation plays a key role in MARCKS cycling from phospholipid membranes, such as the plasma membrane, to the cytoplasm30, we hypothesize that MARCKS protects neuroepithelial cells from mitochondrial abnormalities and that phosphorylated MARCKS induced by hyperglycemia dissociates from the mitochondrial membrane and does not have a protective effect against the hyperglycemic insult exerted by mitochondria-bound MARCKS on cells. The gene discussed is MARCKS; the disease is Hyperglycemia.