Transient overexpression of ONECUT2 in LNCaP cells, an adeno-PCa cell line, was sufficient to induce the expression of NE marker genes including ASCL1, PEG10, and NSE (Fig. 4a, Supplementary Figure 10a), indicating that ONECUT2 is a regulator of NE plasticity. Here, ONECUT2 is linked to posterior cortical atrophy.