ONECUT2 and neoplasm: Gene Set Enrichment Analysis (GSEA) revealed that ONECUT2 targets genes were enriched with cell cycle related gene sets such as G2M_CHECKPOINT and E2F_TARGETS (Supplementary Figure 5b), in concordance with the function of ONECUT2 in regulating PC3 cell proliferation and tumor growth (Fig. 2a and Supplementary Figure 4c).