ONECUT2 and neoplasm: In line with the tumor inhibition effects, PIMO staining in PC3 xenografts was much stronger than in V16A xenografts (Figs. 2f and 5f; Supplementary Figure 6a and 13e), and ONECUT2 knockdown reduced tumor hypoxia in PC3 xenografts, while ONECUT2 overexpression increased tumor hypoxia in V16A xenografts (Figs. 2f and 5f).