Pre-treatment of HVECs or HCECs with 100 ng of IFN-β or IFN-λ1 reduced ZIKV infection by 32 to 39-fold (HVECs) (P < 0.05) or 695 to 1575-fold (HCECs) (P < 0.01) compared to mock-treated controls (Fig. 1a, b). Here, IFNL1 is linked to Zika virus infectious disease.