FADS2 and metabolic dysfunction-associated steatotic liver disease: We found an association of higher hepatic FADS2 mRNA expression and serum delta-6 desaturase activity with lower levels of DNA methylation in CpG sites annotated to FADS2. Moreover, DNA methylation levels of FADS2 were linked with the FADS2 genotype, suggesting a novel mechanism for the genetic contribution of FADS2 genotypes in the pathogenesis of NAFLD.