FADS2 and metabolic dysfunction-associated steatohepatitis: In this study, subjects with the major allele G had lower DNA methylation levels of cg07999042 in FADS2 compared to homozygotes for the minor allele A. Accordingly, we have shown that the subjects with the major allele G have also higher delta-6 desaturase activity, similarly to patients with NASH [12, 40].