Similarly to H3K27M mutations, H3.3K36M expression in chondroblastoma correlates with global reduction in H3K36 methylation [141], due to inhibition of NSD2/MMSET, a methyltransferase that catalyzes mono- and di-methylation of H3K36, and SETD2, which catalyzes trimethylation of H3K36me2 [141, 142]. Here, NSD2 is linked to chondroblastoma.