An inverse correlation between SIRT6 and TRF2 protein expression levels have been also found in a cohort of CRC patients [114], suggesting that an impairment of TRF2 degradation, as a consequence of SIRT6 loss, could be one of the mechanisms underlying the increased dosages of TRF2 observed in many human malignancies. The gene discussed is SIRT6; the disease is colorectal carcinoma.