The SVR12 rates were high in OBV/PTV/r ± DSV ± RBV for HIV/HCV GT1 coinfected patients regardless of the duration of treatment, regimens, HCV genotypes, history of treatment, and the presence or absence of cirrhosis, baseline HCV RNA, CD4 cell counts, Platelet counts, and IL 28B genotype. The gene discussed is CD4; the disease is Cirrhosis.